منابع مشابه
The importance of epigenetic modifications in cancer progression
Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they ar...
متن کاملEpigenetic Modifications of Host Genes Induced by Bacterial Infection
Introduction: Epigenetic mechanisms regulate expression of the genome to generate various cell types during development or coordinate cellular responses to external stimulus. While epigenetics is of fundamental importance in eukaryotes, it plays a different role in bacteria. This article uncovers the most important recent data on how bacteria can alter epigenetic marks and can also contribute t...
متن کاملEpigenetic modifications in cancer.
Cancer initiation and progression is controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot be accounted for by genetic alterations alone but also involves epigenetic changes. Epigenetics refers to the study of mechanisms that alter gene expression without altering the primary DNA sequence. Epigenetic mechanisms are heritable and reversible, and include change...
متن کاملEpigenetic Modifications in Liver Fibrosis
35 Received October 10, 2012; accepted November 21, 2012. Published online December 12, 2012; doi: 10.1620/tjem.229.35. *Qi Zhao and Cheng-Yong Qin contributed equally to this work. Correspondence: Kai Wang, M.D., Ph.D., Department of Hepatology, Qilu Hospital of Shandong University and Institute of Hepatology, Shandong University, 107# Wenhuaxi Road, Jinan, Shangdong 250012, P.R. China. e-mail...
متن کاملEpigenetic Modifications during Angiosperm Gametogenesis
Angiosperms do not contain a distinct germline, but rather develop gametes from gametophyte initials that undergo cell division. These gametes contain cells that give rise to an endosperm and the embryo. DNA methylation is decreased in the vegetative nucleus (VN) and central cell nuclei (CCN) resulting in expression of transposable elements (TEs). It is thought that the siRNAs produced in respo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.110.956839